Functional Repetitive Neuromuscular Magnetic Stimulation (frNMS) Targeting the Tibialis Anterior Muscle in Children with Upper Motor Neuron Syndrome: A Feasibility Study

Non-invasive neurostimulation as an adjunctive intervention to task-specific motor training is approach foster performance in patients affected by upper neuron syndrome (UMNS). Here, we present first-line data of repetitive neuromuscular magnetic stimulation (rNMS) combination with personalized physical exercises targeting the tibialis anterior muscle improve ankle dorsiflexion (functional rNMS (frNMS)). The main objective this pilot study was assess feasibility terms adherence frNMS, safety and practicability satisfaction frNMS. First, during 10 sessions, only were performed (study period (SP) A). After a 1 week break, frNMS delivered sessions (SPC). Twelve children UMNS (mean age 8.9 ± 1.6 years) adhered 93% (SPA) 94% (SPC) omittance not related itself any case. safe (no AEs reported 88% no AE-related discontinuation). high. Patient/caregiver-reported outcomes revealed meaningful benefits on individual level. strength dorsiflexors (MRC score) clinically meaningfully increased four participants spasticity plantar flexors (Tardieu scores) decreased after SPC. experienced feasible for UMNS. Together beneficial effects achieved level some participants, first supports further real-world, large-scale, sham-controlled investigations investigate specific distinct mechanisms action